SUNGKYUNKWAN UNIVERSITY SCHOOL OF MEDICINE
CLOSE HEADER
Laboratory
Neuropathophysiology(신경병태연구실)
Sungkwon Chung
Cholesterol Regulation of Amyloid Production Laboratory
Alzheimer’s Disease (AD) is a typical neurodegenerative disease caused by increased amyloid b-protein (Ab) production. One of main genetic cause of AD is mutations in presenilin protein, which increases the production of Ab. We previously reported for the first time that presenilin mutation induces calcium signaling dysfunction (Yoo et al., Neuron, 2000). We also reported that presenilin mutation decreases one of major lipid component in plasma membrane (PIP2), which resulted in the decreased TRPM7 channel activity (Landman et al., PNAS, 2006). Currently, we study the molecular mechanism for the regulation of Ab production in relation to calcium signaling. Based on our research results, we also try to find a new target for therapeutic drugs for AD.
[Selected Publications]
1. Kwon OH, Cho YY, Kim TW, Chung SO-GlcNAcylation of amyloid-b protein precursor by insulin signaling reduces amyloid&8211b production. (2019). J. Alzheimer’s Disease 69:1195.
2. Chun YS, Zhang L, Li H, Park Y , Chung S*, Yang HO* (2018) 7-Deoxy-trans-dihydronarciclasine Reduces β-Amyloid and Ameliorates Memory Impairment in a Transgenic Model of Alzheimer’s Disease. Mol. Neurobiol. 55:8953. *co-corresponding authors
3. Chun YS, Park Y, Oh HG, Kim T-W, Yang H, Park M, Chung S (2015) O-GlcNAcylation promotes non-amyloidogenic processing of amyloid-b protein precursor via inhibition of endocytosis from the plasma membrane. J. Alzheimer’s Disease 44:261.
4. Kim J, Park Y, Chun Y, Cha JW, Kwon HC, Oh MS, Chung S*, Yang HO* (2015) Effect of Lycoris chejuensis and Its Active Components on Experimental Models of Alzheimers Disease. J Agric. Food Chem. 63:6979. *co-corresponding authors
5. Oh HG, Chun YS, Park C-S, Kim T-W, Park MK, Chung S (2015) Regulation of basal autophagy by transient receptor potential melastatin 7 (TRPM7) channel. Biochem Biophys Res Commun. 463:7.
6. Kang MS, Baek S-H, Chun YS, Moore Z, Landman N, Bergman D, Yang HO, Morishima-Kawashima M, Osawa S, Funamoto S, Ihara Y, Di Paolo G, Park JH, Chung S*, Kim T-W* (2013) Modulation of lipid kinase PI4KIIa activity and lipid raft association of presenilin 1 underlies g-secretase inhibition by ginsenoside (20S)Rg3. J. Biol. Chem. 288:20868. *co-corresponding authors
7. Landman N, Serban G, Shin SY, Kang MS, Chung S*, Kim T-W* (2006) An essential role for phosphatidylinositol-4,5-bisphosphate in familial Alzheimer¡&175s disease-linked presenilin mutations. PNAS 103: 19524. *co-corresponding authors
1. Kwon OH, Cho YY, Kim TW, Chung SO-GlcNAcylation of amyloid-b protein precursor by insulin signaling reduces amyloid&8211b production. (2019). J. Alzheimer’s Disease 69:1195.
2. Chun YS, Zhang L, Li H, Park Y , Chung S*, Yang HO* (2018) 7-Deoxy-trans-dihydronarciclasine Reduces β-Amyloid and Ameliorates Memory Impairment in a Transgenic Model of Alzheimer’s Disease. Mol. Neurobiol. 55:8953. *co-corresponding authors
3. Chun YS, Park Y, Oh HG, Kim T-W, Yang H, Park M, Chung S (2015) O-GlcNAcylation promotes non-amyloidogenic processing of amyloid-b protein precursor via inhibition of endocytosis from the plasma membrane. J. Alzheimer’s Disease 44:261.
4. Kim J, Park Y, Chun Y, Cha JW, Kwon HC, Oh MS, Chung S*, Yang HO* (2015) Effect of Lycoris chejuensis and Its Active Components on Experimental Models of Alzheimers Disease. J Agric. Food Chem. 63:6979. *co-corresponding authors
5. Oh HG, Chun YS, Park C-S, Kim T-W, Park MK, Chung S (2015) Regulation of basal autophagy by transient receptor potential melastatin 7 (TRPM7) channel. Biochem Biophys Res Commun. 463:7.
6. Kang MS, Baek S-H, Chun YS, Moore Z, Landman N, Bergman D, Yang HO, Morishima-Kawashima M, Osawa S, Funamoto S, Ihara Y, Di Paolo G, Park JH, Chung S*, Kim T-W* (2013) Modulation of lipid kinase PI4KIIa activity and lipid raft association of presenilin 1 underlies g-secretase inhibition by ginsenoside (20S)Rg3. J. Biol. Chem. 288:20868. *co-corresponding authors
7. Landman N, Serban G, Shin SY, Kang MS, Chung S*, Kim T-W* (2006) An essential role for phosphatidylinositol-4,5-bisphosphate in familial Alzheimer¡&175s disease-linked presenilin mutations. PNAS 103: 19524. *co-corresponding authors
(Tel) +82-31-299-6103,
(Email) schung@skku.edu