SUNGKYUNKWAN UNIVERSITY SCHOOL OF MEDICINE
CLOSE HEADER
Laboratory
Pluripotency to Blood Lab (PBL)(인간만능줄기세포연구실)
Ho-Chang Jeong
Hematopoietic development, Disease modeling, Human embryonic stem cells, iPSCs Laboratory
We have focused on disease modeling through human pluripotent stem cell (embryonic stem cell and induced pluripotent stem cell (iPSC))-derived hematopoiesis and bone marrow organoids to understand pathogenic mechanisms of blood diseases and blood cancer-related disorders. Hematopoiesis occurs by the self-division and differentiation of hematopoietic stem progenitor cells (HSPCs) in the bone marrow, of which research can be applied to 1) understand the regulation of composition and function of bone marrow/immune cells in the immune system, blood, and peripheral organs, and 2) identify the pathogenesis of incurable blood diseases to develop disease-specific drugs and cell therapies.
[Selected Publications]
1. Jeong HC*, Shukla S*, Fok WC, Huynh TN, Batista LFZ, Parker R “USB1 is a miRNA deadenylase that regulates hematopoietic development” Science. 2023 379(6635): 901-7. (Research Highlighted by Nature Review Genetics: https://www.nature.com/articles/s41576-023-00595-9)
2. Jeong HC*, Go YH*, Shin JG, Kim YJ, Cho MG, Gwon D, Cheong HS, Lee H, Lee JH, Jang CY, Shin HD, Cha HJ “TPX2 amplification-driven aberrant mitosis in culture adapted human embryonic stem cells with gain of 20q11.21” Stem Cell Rev Rep. 2023 doi: 10.1007/s12015-023-10514-4.
3. Shukla S*, Jeong HC*, Sturgeon CM, Parker R, Batista LFZ “Chemical inhibition of PAPD5/7 rescues telomerase function and hematopoiesis in dyskeratosis congenita” Blood Adv. 2020 4(12): 2712-22.
4. Jeong HC, Park SJ, Choi JJ, Go YH, Hong SK, Kwon OS, Shin JG, Kim RK, Lee MO, Lee SJ, Shin HD, Moon SH, Cha HJ “PRMT8 controls the pluripotency and mesodermal fate of human embryonic stem cells by enhancing the PI3K/AKT/SOX2 axis” Stem Cells. 2017 35(9): 2037-49.
5. Jeong HC, Cho SJ, Lee MO, Cha HJ “Technical approaches to induce selective cell death of pluripotent stem cells” Cell Mol Life Sci. 2017 74(14): 2601-11. (Invited Review)
6. Yea CH*, Jeong HC*, Moon SH, Lee MO, Kim KJ, Choi JW, Cha HJ “In situ label-free quantification of human pluripotent stem cells with electrochemical potential” Biomaterials. 2016 75: 250-9.
1. Jeong HC*, Shukla S*, Fok WC, Huynh TN, Batista LFZ, Parker R “USB1 is a miRNA deadenylase that regulates hematopoietic development” Science. 2023 379(6635): 901-7. (Research Highlighted by Nature Review Genetics: https://www.nature.com/articles/s41576-023-00595-9)
2. Jeong HC*, Go YH*, Shin JG, Kim YJ, Cho MG, Gwon D, Cheong HS, Lee H, Lee JH, Jang CY, Shin HD, Cha HJ “TPX2 amplification-driven aberrant mitosis in culture adapted human embryonic stem cells with gain of 20q11.21” Stem Cell Rev Rep. 2023 doi: 10.1007/s12015-023-10514-4.
3. Shukla S*, Jeong HC*, Sturgeon CM, Parker R, Batista LFZ “Chemical inhibition of PAPD5/7 rescues telomerase function and hematopoiesis in dyskeratosis congenita” Blood Adv. 2020 4(12): 2712-22.
4. Jeong HC, Park SJ, Choi JJ, Go YH, Hong SK, Kwon OS, Shin JG, Kim RK, Lee MO, Lee SJ, Shin HD, Moon SH, Cha HJ “PRMT8 controls the pluripotency and mesodermal fate of human embryonic stem cells by enhancing the PI3K/AKT/SOX2 axis” Stem Cells. 2017 35(9): 2037-49.
5. Jeong HC, Cho SJ, Lee MO, Cha HJ “Technical approaches to induce selective cell death of pluripotent stem cells” Cell Mol Life Sci. 2017 74(14): 2601-11. (Invited Review)
6. Yea CH*, Jeong HC*, Moon SH, Lee MO, Kim KJ, Choi JW, Cha HJ “In situ label-free quantification of human pluripotent stem cells with electrochemical potential” Biomaterials. 2016 75: 250-9.
(Tel) +82-31-299-6071,
(Email) hcjeong@skku.edu