SUNGKYUNKWAN UNIVERSITY SCHOOL OF MEDICINE
CLOSE HEADER
Laboratory
1) Mechanism of dopaminergic neuronal death
2) Cellular and physiological roles of KRAB-zinc finger (K-ZNF) proteins in neurons
3) Relationship between neurodegeneration and liquid-liquid phase separation
4) Functional studies of protein lipidation
2) Cellular and physiological roles of KRAB-zinc finger (K-ZNF) proteins in neurons
3) Relationship between neurodegeneration and liquid-liquid phase separation
4) Functional studies of protein lipidation
[Selected Publications]
1. Jo A, Lee Y, Kam TI, Kang SU, Neifert S, Karuppagounder SS, Khang R, Kang H, Park H, Chou SC, Oh S, Jiang H, Swing DA, Ham S, Pirooznia S, Umanah GKE, Mao X, Kumar M, Ko HS, Kang HC, Lee BD, Lee YI, Andrabi SA, Park CH, Lee JY, Kim H, Kim H, Kim H, Cho JW, Paek SH, Na CH, Tessarollo L, Dawson VL, Dawson TM, Shin JH. PARIS farnesylation prevents neurodegeneration in models of Parkinsons disease. Sci. Transl. Med. 2021 Jul 2813(604):eaax8891.
2. Khang R, Jo A, Kang H, Kim H, Kwag E, Lee JY, Koo O, Park J, Kim HK, Jo DG, Hwang I, Ahn JY, Lee Y, Choi JY, Lee YS, Shin JH.Loss of zinc-finger protein 212 leads to Purkinje cell death and locomotive abnormalities with phospholipase D3 downregulation. Sci. Rep. 2021 Nov 2311(1):22745
3. Jo A, Lee Y, Park CH, Shin JH. Deubiquitinase USP29 Governs MYBBP1A in the Brains of Parkinsons Disease Patients. J. Clin. Med. 2019 Dec 249(1):52.
4. Areum Jo, Yunjong Lee, Chi-Hu Park, Joo-Ho Shin* (2019) Deubiquitinase USP29 governs MYBBP1A in the brains of Parkinson’s disease patients. Journal of Clinical Medicine, 9(52).
5. Hojin Kang, Areum Jo, Hyein Kim, Rin Khang, Ji-Yeong Lee, Hanna Kim, Chi-Hu Park, Jeong-Yun Choi, Yunjong Lee, Joo-Ho Shin* (2018) PARIS reprograms glucose metabolism by HIF-1α induction in dopaminergic neurodegeneration. Biochemical and Biophysical Research Communications, 495(4), 2498-2504.
6. Hojin Kang, Rin Khang, Sangwoo Ham, Ga Ram Jeong, Hyojung Kim, Minkyung Jo, Byoung Dae Lee, Yun Il Lee, Areum Jo, ChiHu Park, Hyein Kim, Jeongkon Seo, Sun Ha Paek, Yun-Song Lee, Jeong-Yun Choi, Yunjong Lee* and Joo-Ho Shin* (2017) Activation of the ATF2/CREB-PGC-1α pathway by metformin leads to dopaminergic neuroprotection. Oncotarget, 8(30), 48603-48618.
7. Y Lee, DA. Stevens, S-U Kang, H Jiang, Y-I Lee, HS Ko, LA. Scarffe, GE. Umanah, H Kang, S Ham, T-I Kam, K Allen, S Brahmachari, JW Kim, S Neifert, SP Yun, FC. Fiesel, W Springer, VL. Dawson*, J-H Shin*, TM. Dawson* (2017) PINK1 Primes Parkin-Mediated Ubiquitination of PARIS in Dopaminergic Neuronal Survival. Cell Report, 18(4), 918-932.
8. Yun-Il Lee, Hojin Kang, Young Wan Ha, Ki-Young Chang, Sung-Chun Cho, Sang Ok Song, Hyein Kim, Areum Jo, Rin Khang, Jeong-Yun Choi, Yunjong Lee, Sang Chul Park, Joo-Ho Shin* (2016) Diaminodiphenyl sulfone&8211induced parkin ameliorates age-dependent dopaminergic neuronal loss. Neurobiology of Aging, 41, 1-10.
9. Daniel A. Stevens, Yunjong Lee, Ho Chul Kang, Byoung Dae Lee, Yun-Il Lee, Aaron Bower, Haisong Jiang, Sung-Ung Kang, Shaida A. Andrabi, Valina L. Dawson, Joo-Ho Shin* and Ted M. Dawson* (2015) Parkin loss leads to PARIS-dependent declines in mitochondrial mass and respiration. Proceedings of the National Academy of Sciences of the United States of America, 112(37), 11696-11701 *Corresponding author
1. Jo A, Lee Y, Kam TI, Kang SU, Neifert S, Karuppagounder SS, Khang R, Kang H, Park H, Chou SC, Oh S, Jiang H, Swing DA, Ham S, Pirooznia S, Umanah GKE, Mao X, Kumar M, Ko HS, Kang HC, Lee BD, Lee YI, Andrabi SA, Park CH, Lee JY, Kim H, Kim H, Kim H, Cho JW, Paek SH, Na CH, Tessarollo L, Dawson VL, Dawson TM, Shin JH. PARIS farnesylation prevents neurodegeneration in models of Parkinsons disease. Sci. Transl. Med. 2021 Jul 2813(604):eaax8891.
2. Khang R, Jo A, Kang H, Kim H, Kwag E, Lee JY, Koo O, Park J, Kim HK, Jo DG, Hwang I, Ahn JY, Lee Y, Choi JY, Lee YS, Shin JH.Loss of zinc-finger protein 212 leads to Purkinje cell death and locomotive abnormalities with phospholipase D3 downregulation. Sci. Rep. 2021 Nov 2311(1):22745
3. Jo A, Lee Y, Park CH, Shin JH. Deubiquitinase USP29 Governs MYBBP1A in the Brains of Parkinsons Disease Patients. J. Clin. Med. 2019 Dec 249(1):52.
4. Areum Jo, Yunjong Lee, Chi-Hu Park, Joo-Ho Shin* (2019) Deubiquitinase USP29 governs MYBBP1A in the brains of Parkinson’s disease patients. Journal of Clinical Medicine, 9(52).
5. Hojin Kang, Areum Jo, Hyein Kim, Rin Khang, Ji-Yeong Lee, Hanna Kim, Chi-Hu Park, Jeong-Yun Choi, Yunjong Lee, Joo-Ho Shin* (2018) PARIS reprograms glucose metabolism by HIF-1α induction in dopaminergic neurodegeneration. Biochemical and Biophysical Research Communications, 495(4), 2498-2504.
6. Hojin Kang, Rin Khang, Sangwoo Ham, Ga Ram Jeong, Hyojung Kim, Minkyung Jo, Byoung Dae Lee, Yun Il Lee, Areum Jo, ChiHu Park, Hyein Kim, Jeongkon Seo, Sun Ha Paek, Yun-Song Lee, Jeong-Yun Choi, Yunjong Lee* and Joo-Ho Shin* (2017) Activation of the ATF2/CREB-PGC-1α pathway by metformin leads to dopaminergic neuroprotection. Oncotarget, 8(30), 48603-48618.
7. Y Lee, DA. Stevens, S-U Kang, H Jiang, Y-I Lee, HS Ko, LA. Scarffe, GE. Umanah, H Kang, S Ham, T-I Kam, K Allen, S Brahmachari, JW Kim, S Neifert, SP Yun, FC. Fiesel, W Springer, VL. Dawson*, J-H Shin*, TM. Dawson* (2017) PINK1 Primes Parkin-Mediated Ubiquitination of PARIS in Dopaminergic Neuronal Survival. Cell Report, 18(4), 918-932.
8. Yun-Il Lee, Hojin Kang, Young Wan Ha, Ki-Young Chang, Sung-Chun Cho, Sang Ok Song, Hyein Kim, Areum Jo, Rin Khang, Jeong-Yun Choi, Yunjong Lee, Sang Chul Park, Joo-Ho Shin* (2016) Diaminodiphenyl sulfone&8211induced parkin ameliorates age-dependent dopaminergic neuronal loss. Neurobiology of Aging, 41, 1-10.
9. Daniel A. Stevens, Yunjong Lee, Ho Chul Kang, Byoung Dae Lee, Yun-Il Lee, Aaron Bower, Haisong Jiang, Sung-Ung Kang, Shaida A. Andrabi, Valina L. Dawson, Joo-Ho Shin* and Ted M. Dawson* (2015) Parkin loss leads to PARIS-dependent declines in mitochondrial mass and respiration. Proceedings of the National Academy of Sciences of the United States of America, 112(37), 11696-11701 *Corresponding author
(Tel) +82-31-299-6192,
(Email) jshin24@skku.edu