Neural Development and Disease Lab(신경생화학실험실)

Jee-Yin Ahn

Brain Development / Death and Recovery of Neurons Laboratory
The goal of our research is to identify the fundamental mechanisms and principles that govern neuronal death and connectivity of neural circuits in the brain development and disease and to determine how these mechanisms are deregulated in neurological diseases. Currently our lab focused on the elucidation of 1) the regulation of neuron death in brain disease, 2) the intrinsic mechanisms regulating the neural development including growth cone formation and synapse function and 2) the manipulation of this intrinsic growth control pathway as a therapeutic approach to promote axon regeneration after CNS injury
1. Inwoo Hwang and Jee-Yin Ahn., 2020: Dysregulation of Epigenetic Control Contributes to Schizophrenia-Like Behavior in Ebp1 +/&8722 Mice. International Journal of Molecular Sciences

2. Hyo Rim Ko et al., 2019: Roles of ErbB3-binding protein 1 (EBP1) in embryonic development and gene-silencing control. PNAS

3. Hyo Rim Ko et al., 2019: SIAH1 ubiquitin ligase mediates ubiquitination and degradation of Akt3 in neural development. Journal of Biological Chemistry

4. Inwoo Hwang et al., 2018: Chaperone-E3 Ligase Complex HSP70-CHIP Mediates Ubiquitination of Ribosomal Protein S3. International Journal of Molecular Sciences

5. Hyo Rim Ko et al., 2016: Akt1/Inhibitor of DNA binding2 is essential for growth cone formation and axon growth and promotes central nervous system axon regeneration. eLIFE
(Tel) +82-31-299-6134,  (Email)