SUNGKYUNKWAN UNIVERSITY SCHOOL OF MEDICINE
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Research Highlights
Synthetic lethality-mediated precision oncology via the tumor transcriptome
이주상 교수(교신저자/제1저자/성균관대학교), 정영민/김다솔 (공동저자/성균관대학교)
CELL
- SELECT (Synthetic lEthaLity and rescue-mediated prECision oncology via the Transcriptome) provides the first unified framework of precision oncology via a novel concept of synthetic lethality and tumor transcriptome.
- SELECT predicts therapy response in 28 of the 35 targeted and immunotherapy trials with a considerable accuracy (>0.7 of AUC of ROC curve).
- SELECT is expected to facilitate patient stratification based on transcriptomic data based on our retrospective analysis of three of multi-arm clinical trials.
- SELECT predicts therapy response in 28 of the 35 targeted and immunotherapy trials with a considerable accuracy (>0.7 of AUC of ROC curve).
- SELECT is expected to facilitate patient stratification based on transcriptomic data based on our retrospective analysis of three of multi-arm clinical trials.