SUNGKYUNKWAN UNIVERSITY SCHOOL OF MEDICINE
CLOSE HEADER
Research Highlights
Cdon ablation in motor neurons causes age-related motor neuron degeneration and impaired sciatic nerve repair
S Kim, S An , J Lee, Y Jeong, C-L You, H Kim, J-H Bae, C-E Yun, D Ryu, G-U Bae, J-S Kang
Journal of Cachexia, Sarcopenia and Muscle
▷ Motor neuron diseases and muscle wasting with age are closely linked to the loss of motor neurons, although the precise underlying mechanism remains undiscovered.
▷ This study investigated the role of Cdon (cell adhesion molecule-downregulated oncogene) in adult motor neurons by generating Hb9-Cre recombinase-driven motor neuron-specific Cdon deficient mice (mnKO).
▷ Mice lacking Cdon in motor neurons exhibited lethality beginning in middle age and age-related decline in motor function. The mnKO mice also exhibited an impairment in motor function recovery following sciatic nerve crush injury along with reinnervation and myelination defect.
▷ RNA sequencing of mnKO lumbar spinal cords showed alteration in genes related to neurogenesis, inflammation, and cell death. Notably, ErbB4and FgfR expressions were significantly altered in mnKO.
▷ Consistently, Cdon-depleted NSC34 cells exhibited reduced activation of Akt in response to neuregulin-1 (NRG1) treatment and displayed elevated levels of cell death and stress markers.
▷ The current study underscores the functional significance of Cdon in adult motor neurons and nerve repair by modulating neurotrophin signaling pathway.
▷ This study investigated the role of Cdon (cell adhesion molecule-downregulated oncogene) in adult motor neurons by generating Hb9-Cre recombinase-driven motor neuron-specific Cdon deficient mice (mnKO).
▷ Mice lacking Cdon in motor neurons exhibited lethality beginning in middle age and age-related decline in motor function. The mnKO mice also exhibited an impairment in motor function recovery following sciatic nerve crush injury along with reinnervation and myelination defect.
▷ RNA sequencing of mnKO lumbar spinal cords showed alteration in genes related to neurogenesis, inflammation, and cell death. Notably, ErbB4and FgfR expressions were significantly altered in mnKO.
▷ Consistently, Cdon-depleted NSC34 cells exhibited reduced activation of Akt in response to neuregulin-1 (NRG1) treatment and displayed elevated levels of cell death and stress markers.
▷ The current study underscores the functional significance of Cdon in adult motor neurons and nerve repair by modulating neurotrophin signaling pathway.